Nanomedicine as a future therapeutic approach for Hepatitis C virus

NH Abd Ellah, HM Tawfeek, J John, HF Hetta - Nanomedicine, 2019 - Taylor & Francis
Hepatitis C virus (HCV) is not easily cleared from the human body and in most cases turned
into chronic infection. This chronicity is a major cause of liver damage, cirrhosis and …

T follicular helper and T follicular regulatory cells in colorectal cancer: a complex interplay

HF Hetta, A Elkady, R Yahia, AK Meshall… - Journal of …, 2020 - Elsevier
Colorectal cancer is considered to be one of the major causes of morbidity and mortality all
over the world. T Follicular helper (T FH) and T follicular regulatory (T FR) cells are …

Prevalence and predictors of occult hepatitis C virus infection among Egyptian patients who achieved sustained virologic response to sofosbuvir/daclatasvir therapy: a …

MA Mekky, HI Sayed, MO Abdelmalek… - Infection and drug …, 2019 - Taylor & Francis
Background Occult hepatitis C virus (HCV) infection (OCI) is characterized by the detection
of HCV-RNA in non-serum reservoirs, such as peripheral blood mononuclear cells (PBMCs) …

Increased frequency and FOXP3 expression of human CD8+ CD25High+ T lymphocytes and its relation to CD4 regulatory T cells in patients with hepatocellular …

AM Zahran, H Nafady-Hego, SG Mansor, WA Abbas… - Human immunology, 2019 - Elsevier
The mechanism of action of CD8+ CD25 High+ FOXP3+ T cells in hepatocellular carcinoma
(HCC) has not been fully understood. Herein, the role of CD8+ CD25 High+ FOXP3+ T cells …

Investigating virological, immunological, and pathological avenues to identify potential targets for developing covid-19 treatment and prevention strategies

Z Mahmood, H Alrefai, HF Hetta, H A. Kader… - Vaccines, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging
coronavirus causing respiratory disease commonly known as COVID-19. This novel …

Impact of interleukin IL-6 rs-1474347 and IL-10 rs-1800896 genetic polymorphisms on the susceptibility of HCV-infected Egyptian patients to hepatocellular carcinoma

RM Abd El-Baky, HF Hetta, G Koneru, M Ammar… - Immunologic …, 2020 - Springer
Hepatitis C virus (HCV) is considered leading cause of cirrhosis and hepatocellular
carcinoma (HCC). We aimed to examine the association of IL-6 and IL-10 single-nucleotide …

Metoclopramide nanoparticles modulate immune response in a diabetic rat model: association with regulatory T cells and proinflammatory cytokines

NH Abd Ellah, EA Ahmed, RB Abd-Ellatief… - International Journal …, 2019 - Taylor & Francis
Background The inflammatory basis of diabetes mellitus directed the researchers' attention
to the immune system for better management and prevention of complications …

Frequency and Implications of myeloid‐derived suppressor cells and lymphocyte subsets in Egyptian patients with hepatitis C virus‐related hepatocellular carcinoma

HF Hetta, AM Zahran, SG Mansor… - Journal of Medical …, 2019 - Wiley Online Library
Background and aim Myeloid‐derived suppressor cells (MDSCs) play a pivotal role in tumor
immunity and induction of immune tolerance to a variety of antitumor effectors, including T …

Regulatory B cells and their cytokine profile in HCV-related hepatocellular carcinoma: association with regulatory T cells and disease progression

HF Hetta, MA Mekky, AM Zahran, MO Abdel-Malek… - Vaccines, 2020 - mdpi.com
Although regulatory B cells (Bregs) have been proven to play a suppressive role in
autoimmune diseases, infections and different tumors, little is known regarding …

Distribution of naturally-occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C

HR Ahmed, NGFM Waly, RM Abd El-Baky, R Yahia… - PloS one, 2021 - journals.plos.org
Background NS5B polymerase inhibitors represent the cornerstone of the present treatment
of Hepatitis C virus infection (HCV). Naturally occurring substitution mutations to NS5B …