The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

In this review article about fibrosis and arrhythmias, we show that the amount of collagen, a
normal element of the heart muscle, increases with age and in heart disease. The relation …

Mitochondrial defects have been found in aging and several age‐related diseases. Mice
with a homozygous mutation in the exonuclease encoding domain of mitochondrial DNA …

Emerging evidence suggests that atrial fibrillation (AF) may be associated with an increased
risk of sudden cardiac death (SCD). However, AF shares risk factors with numerous cardiac …

Myocardial fibrosis is an important risk factor for cardiac arrhythmias. Previous experimental
and numerical studies have shown that the texture and spatial distribution of fibrosis may …

BACKGROUND: Reduced expression of connexin43 (Cx43) and sodium channel (Nav1. 5)
and increased expression of collagen (fibrosis) are important determinants of impulse …

Right ventricular failure predicts adverse outcome in patients with pulmonary hypertension
(PH), and in subjects with left ventricular heart failure and is associated with interstitial …

Increased cardiac collagen deposition is observed in almost every cardiac disease and
plays an important role in the deteriorating function of the diseased heart. Propeptides of …

This review aims to highlight the normal physiological remodeling that occurs in healthy
aging hearts, including changes that occur in contractility, conduction, valve function, large …

Aging is a progressive decline of body function, during which many tissues accumulate few
cells with high levels of deleted mitochondrial DNA (mtDNA), leading to a defect of …