New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

The first clinical description of Parkinson's disease (PD) will embrace its two century
anniversary in 2017. For the past 30 years, mitochondrial dysfunction has been …

Mutations of LRRK2, encoding leucine-rich repeat kinase 2 (LRRK2), are the leading cause
of autosomal dominant Parkinson's disease (PD). The most frequent of these mutations …

Mitochondrial dysfunction causes energy deficiency and nigrostriatal neurodegeneration
which is integral to the pathogenesis of Parkinson disease (PD). Clearance of defective …

The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has
been studied extensively in the brain. However, several studies have established that …

Due to their post-mitotic state, metabolic demands and often large polarised morphology, the
function and survival of neurons is dependent on an efficient cellular waste clearance …

The heterogenous aetiology of Parkinson's disease is increasingly recognized; both
mitochondrial and lysosomal dysfunction have been implicated. Powerful, clinically …

This article describes pathogenic concepts and factors, in particular glycolipid abnormalities,
that create cell dysfunction and synaptic loss in neurodegenerative diseases. By …