Transport and interactions of nanoparticles in the kidneys

B Du, M Yu, J Zheng - Nature Reviews Materials, 2018 - nature.com
Kidneys are a major organ for blood filtration and waste elimination and thus play a key role
in the transport and clearance of nanoparticles in vivo. The interactions of nanoparticles with …

Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system

T Neuberger, B Schöpf, H Hofmann, M Hofmann… - Journal of Magnetism …, 2005 - Elsevier
Nanoparticles can be used in biomedical applications, where they facilitate laboratory
diagnostics, or in medical drug targeting. They are used for in vivo applications such as …

Nanoparticles for imaging: top or flop?

F Kiessling, ME Mertens, J Grimm, T Lammers - Radiology, 2014 - pubs.rsna.org
Nanoparticles are frequently suggested as diagnostic agents. However, except for iron oxide
nanoparticles, diagnostic nanoparticles have been barely incorporated into clinical use so …

MRI detection of single particles for cellular imaging

EM Shapiro, S Skrtic, K Sharer, JM Hill… - Proceedings of the …, 2004 - National Acad Sciences
There is rapid growth in the use of MRI for molecular and cellular imaging. Much of this work
relies on the high relaxivity of nanometer-sized, ultrasmall dextran-coated iron oxide …

In situ labeling of immune cells with iron oxide particles: An approach to detect organ rejection by cellular MRI

YL Wu, Q Ye, LM Foley, TK Hitchens… - Proceedings of the …, 2006 - National Acad Sciences
In vivo cell tracking by MRI can provide means to observe biological processes and monitor
cell therapy directly. Immune cells, eg, macrophages, play crucial roles in many …

Receptor‐mediated endocytosis of iron‐oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging

ET Ahrens, M Feili‐Hariri, H Xu… - … in Medicine: An …, 2003 - Wiley Online Library
Dendritic cells (DCs) function as antigen presenting cells in vivo and play a fundamental role
in numerous diseases. New methods are described for high‐efficiency intracellular labeling …

Radiologic imaging of the renal parenchyma structure and function

N Grenier, P Merville, C Combe - Nature Reviews Nephrology, 2016 - nature.com
Radiologic imaging has the potential to identify several functional and/or structural
biomarkers of acute and chronic kidney diseases that are useful diagnostics to guide patient …

19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells

TK Hitchens, Q Ye, DF Eytan, JM Janjic… - Magnetic resonance …, 2011 - Wiley Online Library
Current diagnosis of organ rejection following transplantation relies on tissue biopsy, which
is not ideal due to sampling limitations and risks associated with the invasive procedure. We …

[HTML][HTML] Towards non-invasive diagnostic techniques for early detection of acute renal transplant rejection: A review

E Hollis, M Shehata, F Khalifa, M Abou El-Ghar… - The Egyptian Journal of …, 2017 - Elsevier
The kidney is a very important complicated filtering organ of the body. When the kidney
reaches stage 5 chronic kidney disease, end stage renal failure, the preeminent therapy is …

Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano-and micron-sized superparamagnetic iron-oxide …

L Liu, TK Hitchens, Q Ye, Y Wu, B Barbe… - … et Biophysica Acta (BBA …, 2013 - Elsevier
BACKGROUND: Superparamagnetic iron-oxide nanoparticles are useful as contrast agents
for anatomical, functional and cellular MRI, drug delivery agents, and diagnostic biosensors …