Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

Abstract PNPLA3 (adiponutrin), a novel patatin‐like phospholipase domain‐containing
enzyme, is expressed at high level in fat, but also in other tissues including liver …

Genome‐wide association studies identified single‐nucleotide polymorphisms (SNPs) that
are associated with increased hepatic fat or elevated liver enzymes, presumably reflecting …

Single nucleotide polymorphisms (SNPs) near 7 loci have been associated with liver
function tests or with liver steatosis by magnetic resonance spectroscopy. In this study we …

Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin
receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 …

PNPLA3 (adiponutrin, calcium-independent phospholipase A 2 epsilon [iPLA 2∊]) is an
adipose-enriched, nutritionally regulated protein that belongs to the patatin-like …

Ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal
desquamation over the whole body, for which the genetic causes of several human forms …

In the last three decades the incidence of metabolic syndrome (MetS) has been growing
worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty …

Obesity is an important clinical and public health challenge, epitomized by excess adipose
tissue accumulation resulting from an imbalance in energy intake and energy expenditure. It …

Hyperhomocysteinemia (HHcy) is an independent risk factor for coronary artery disease.
Emerging evidence suggests that HHcy is also associated with adipocyte tissue dysfunction …