Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling
RA Coleman, DG Mashek - Chemical reviews, 2011 - ACS Publications
Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …
[PDF][PDF] Patatin‐like phospholipase domain‐containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
Abstract PNPLA3 (adiponutrin), a novel patatin‐like phospholipase domain‐containing
enzyme, is expressed at high level in fat, but also in other tissues including liver …
enzyme, is expressed at high level in fat, but also in other tissues including liver …
[PDF][PDF] The association of genetic variability in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver …
Genome‐wide association studies identified single‐nucleotide polymorphisms (SNPs) that
are associated with increased hepatic fat or elevated liver enzymes, presumably reflecting …
are associated with increased hepatic fat or elevated liver enzymes, presumably reflecting …
[PDF][PDF] PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease
EK Speliotes, JL Butler, CD Palmer, BF Voight… - …, 2010 - Wiley Online Library
Single nucleotide polymorphisms (SNPs) near 7 loci have been associated with liver
function tests or with liver steatosis by magnetic resonance spectroscopy. In this study we …
function tests or with liver steatosis by magnetic resonance spectroscopy. In this study we …
Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity
M Asai, S Ramachandrappa, M Joachim, Y Shen… - Science, 2013 - science.org
Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin
receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 …
receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 …
[HTML][HTML] Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome [S]
MK Basantani, MT Sitnick, L Cai, DS Brenner… - Journal of lipid …, 2011 - ASBMB
PNPLA3 (adiponutrin, calcium-independent phospholipase A 2 epsilon [iPLA 2∊]) is an
adipose-enriched, nutritionally regulated protein that belongs to the patatin-like …
adipose-enriched, nutritionally regulated protein that belongs to the patatin-like …
PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans
A Grall, E Guaguère, S Planchais, S Grond, E Bourrat… - Nature …, 2012 - nature.com
Ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal
desquamation over the whole body, for which the genetic causes of several human forms …
desquamation over the whole body, for which the genetic causes of several human forms …
Non-alcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment
In the last three decades the incidence of metabolic syndrome (MetS) has been growing
worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty …
worldwide along with an increase of obesity, type 2 diabetes mellitus, and non-alcoholic fatty …
[HTML][HTML] Genetic & epigenetic approach to human obesity
KR Rao, N Lal, NV Giridharan - Indian Journal of Medical …, 2014 - journals.lww.com
Obesity is an important clinical and public health challenge, epitomized by excess adipose
tissue accumulation resulting from an imbalance in energy intake and energy expenditure. It …
tissue accumulation resulting from an imbalance in energy intake and energy expenditure. It …
Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway
Z Wang, M Pini, T Yao, Z Zhou, C Sun… - American journal …, 2011 - journals.physiology.org
Hyperhomocysteinemia (HHcy) is an independent risk factor for coronary artery disease.
Emerging evidence suggests that HHcy is also associated with adipocyte tissue dysfunction …
Emerging evidence suggests that HHcy is also associated with adipocyte tissue dysfunction …