Ciliogenesis is a complex multistep process used to describe assembly of cilia and flagella.
These organelles play essential roles in motility and signaling on the surface of cells. Cilia …

Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins
have been linked to ciliogenesis, which proceeds through a highly coordinated multistage …

Obtaining the high-resolution structures of proteins and their complexes is a crucial aspect of
understanding the mechanisms of life. Experimental structure determination methods are …

Primary cilia extending from mother centrioles are essential for vertebrate development and
homeostasis maintenance. Centriolar coiled-coil protein 110 (CP110) has been reported to …

Protein phosphorylation is a critical mechanism that biology uses to govern cellular
processes. To study the impact of phosphorylation on protein properties, a fully and …

Immune synapses are formed between immune cells to facilitate communication and
coordinate the immune response. The reorganization of receptors involved in recognition …

Centrosomes are composed of centrioles surrounded by pericentriolar material. The two
centrioles in G1 phase are distinguished by the localization of their appendages in the distal …

Centrosomal protein of 164 kDa (CEP164) is located at distal appendages of primary cilia
and is necessary for basal body (BB) docking to the apical membrane. To investigate the …

Tau tubulin kinase 1 and 2 (TTBK1/2) are highly homologous kinases that are expressed
and mediate disease-relevant pathways predominantly in the brain. Distinct roles for TTBK1 …

Cilia formation is essential for human life. One of the earliest events in the ciliogenesis
program is the recruitment of tau-tubulin kinase 2 (TTBK2) by the centriole distal appendage …