Over 2 years have passed since the start of the COVID-19 pandemic, which has claimed
millions of lives. Unlike the early days of the pandemic, when management decisions were …

The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike
glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its …

Abstract Background Angiotensin receptor blockers (ARBs), such as telmisartan, have been
postulated to treat Covid-19-induced lung inflammation. Methods This is a parallel-group …

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor
clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin …

The pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2) generated much interest on the basic pathogenetic mechanisms through which SARS …

Objectives Acute kidney injury (AKI) is associated with increased mortality among
coronavirus disease 2019 (COVID-19) patients. This meta-analysis aimed to identify risk …

Hypertension is a significant risk factor for cardiovascular diseases. The prevalence of
hypertension and its complications is increasing yearly, yet it remains inadequately …

The impact of pre-existing hypertension on outcomes in patients with the novel corona virus
(SARS-CoV-2) remains controversial. To address this, we examined the impact of pre …

SARS‐CoV‐2 interacting with its receptor, angiotensin‐converting enzyme 2 (ACE2), turns
the host response to viral infection into a dysregulated uncontrolled inflammatory response …

As of December 2021, SARS-CoV-2 had caused over 250 million infections and 5 million
deaths worldwide. Furthermore, despite the development of highly effective vaccines, novel …