Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Intrinsic apoptosis is controlled by the BCL-2 family of proteins but the complexity of intra-
family interactions makes it challenging to predict cell fate via standard molecular biology …

The essential job of precision medicine is to match the right drugs to the right patients. In
cancer, precision medicine has been nearly synonymous with genomics. However, sobering …

Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk
subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph …

Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as
BCR-ABL1–like ALL, is a high-risk subset with a gene expression profile that shares …

Cancers remain a major public health problem worldwide, which still require profound
research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are …

Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk
subtype characterized by genomic alterations that activate cytokine receptor and kinase …

Loss-of-function mutations in genes encoding TET DNA dioxygenase occur frequently in
hematopoietic malignancy, but rarely in solid tumors, which instead commonly have reduced …

Gain-of-function mutations activating JAK/STAT signaling are seen in the majority of patients
with myeloproliferative neoplasms (MPN), most commonly JAK2 V617F. Although clinically …