Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

K Moshksayan, N Kashaninejad, ME Warkiani… - Sensors and Actuators B …, 2018 - Elsevier
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …

Microfluidics‐Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends

Y Wang, Y Gao, Y Song - ChemMedChem, 2022 - Wiley Online Library
Urine biopsy, allowing for the detection, analysis and monitoring of numerous cancer‐
associated urinary biomarkers to provide insights into cancer occurrence, progression and …

An on-chip imaging droplet-sorting system: a real-time shape recognition method to screen target cells in droplets with single cell resolution

M Girault, H Kim, H Arakawa, K Matsuura, M Odaka… - Scientific reports, 2017 - nature.com
A microfluidic on-chip imaging cell sorter has several advantages over conventional cell
sorting methods, especially to identify cells with complex morphologies such as clusters …

A microfluidic platform integrated with field-effect transistors for enumeration of circulating tumor cells

YH Chen, AK Pulikkathodi, YD Ma, YL Wang, GB Lee - Lab on a Chip, 2019 - pubs.rsc.org
Circulating tumor cells (CTCs) are one of the promising cancer biomarkers whose
concentrations are measured not only in the initial diagnostic stages, but also as treatment …

A microfluidic platform for high-purity separating circulating tumor cells at the single-cell level

K Wang, L Zhou, S Zhao, Z Cheng, S Qiu, Y Lu, Z Wu… - Talanta, 2019 - Elsevier
Circulating tumor cells (CTCs) are rare cancer cells that are shed from the tumors into the
peripheral blood and are instrumental in distant metastasis. Early detection of CTCs can …

Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae

R O'Laughlin, M Jin, Y Li, L Pillus, LS Tsimring… - … medicine of aging, 2020 - Elsevier
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb
to the deteriorating effects of aging, so too comes a host of age-related ailments such as …

Trapping and releasing of single microparticles and cells in a microfluidic chip

D Lv, X Zhang, M Xu, W Cao, X Liu, J Deng… - …, 2022 - Wiley Online Library
A microfluidic device was designed and fabricated to capture single microparticles and cells
by using hydrodynamic force and selectively release the microparticles and cells of interest …

Separation of fine particles and liquid using a physical trapping method via a stepped structure

M Horade, K Misu, T Usagawa, T Yamawaki… - Microsystem …, 2024 - Springer
This study investigated a component separation method using a microfluidic device.
Specifically, we integrated a micron-scale stepped structure, which is a component of a …

Confined cell migration and asymmetric hydraulic environments to evaluate the metastatic potential of cancer cells

Y Juste-Lanas, PE Guerrero… - Journal of …, 2022 - asmedigitalcollection.asme.org
Metastasis, a hallmark of cancer development, is also the leading reason for most cancer-
related deaths. Furthermore, cancer cells are highly adaptable to micro-environments and …

Efficient low Shear Flow-based trapping of Biological entities

A Sohrabi Kashani, M Packirisamy - Scientific Reports, 2019 - nature.com
Capturing cells or biological entities is an important and challenging step toward in-vitro
studies of cells under a precisely controlled microscale environment. In this work, we have …