Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …

Rho GTPases play an essential role in regulating cell spreading, adhesion, and migration
downstream of integrin engagement with the extracellular matrix. In this review, we focus on …

Cell migration controls developmental processes (gastrulation and tissue patterning), tissue
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …

Many fundamental processes in cell biology are regulated by Rho GTPases, including cell
adhesion, migration and differentiation. While regulating cellular functions, members of the …

Mitochondria are dynamic organelles, undergoing both fission and fusion regularly in
interphase cells. Mitochondrial fission is thought to be part of a quality-control mechanism …

The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell
morphology, with a role in several essential cellular processes, including cell migration and …

Cell migration directed by spatial cues, or taxis, is a primary mechanism for orchestrating
concerted and collective cell movements during development, wound repair, and immune …

Cells migrate through 3D environments using a surprisingly wide variety of molecular
mechanisms. These distinct modes of migration often rely on the same intracellular …

Members of the nonmuscle myosin-2 (NM-2) family of actin-based molecular motors
catalyze the conversion of chemical energy into directed movement and force thereby acting …

Nonmuscle myosin II (NMII) is a multimeric protein complex that generates most mechanical
force in eukaryotic cells. NMII function is controlled at three main levels. The first level …