The biomineral haemozoin, or its synthetic analogue β-haematin (βH), has been the focus of
several target-based screens for activity against Plasmodium falciparum parasites. Together …

Background Emergence of cross-resistance to current anti-malarial drugs has led to an
urgent need for identification of potential compounds with novel modes of action and anti …

N-Tosylhydrazones are highly versatile precursors for in situ carbene formation and are
frequently used in metal-catalyzed cross-coupling reactions. Due to their many applications …

In silico adsorption of eight antimalarials that inhibit β‐hematin (synthetic hemozoin)
formation identified a primary binding site on the (001) face, which accommodates inhibitors …

To understand the property space of antimalarials, we collated a large dataset of research
antiplasmodial (RAP) molecules with known in vitro potencies and advanced stage …

N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by
combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models …

Artemisinins tested against W-2 strains of malaria falciparum are investigated with molecular
electrostatic potential (MEP), in an attempt to identify key features of the compounds that are …

Hemozoin is a natural biomarker formed during the hemoglobin metabolism of
Plasmodiumparasites, the causative agents of malaria. The rotating-crystal magneto-optical …