MicroRNAs (miRNAs) are a specialized class of small silencing RNAs that regulate gene
expression. They have a limited phylogenetic distribution among eukaryotes, suggestive of …

Leishmania amastigotes primarily proliferate within macrophages in the mammalian host.
Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and …

Leishmania parasites cause a spectrum of clinical pathology in humans ranging from
disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference …

Kinetoplastids branched early from the eukaryotic lineage and include several parasitic
protozoan species. Up to several hundred kinetoplastid genes are co-transcribed into …

Neutrophils play an active role in the control of infections caused by intracellular pathogens
such as Leishmania. In the present study, we investigated the effect of neutrophil depletion …

The presence of an RNA virus in a South American subgenus of the Leishmania parasite,
L.(Viannia), was detected several decades ago but its role in leishmanial virulence and …

We present the sequencing and annotation of the Leishmania (Leishmania) amazonensis
genome, an etiological agent of human cutaneous leishmaniasis in the Amazon region of …

This review gives an update of current knowledge on the clinical pleiomorphism of
Leishmania, with a special emphasis on the case of asymptomatic carriage. The first part …

Real-time PCR was developed to quantify Leishmania infantum kinetoplast DNA and
optimized to achieve a sensitivity of 1 parasite/mL. For this purpose, we cloned the …

Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic
infections affecting millions of people across the subtropics. Symptoms range from the more …