Recent progress in the development of fluorescent probes for imaging pathological oxidative stress
Y Geng, Z Wang, J Zhou, M Zhu, J Liu… - Chemical Society …, 2023 - pubs.rsc.org
Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …
Ferroptosis and its potential role in the physiopathology of Parkinson's Disease
L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …
characterised by motor impairments as well as non-motor symptoms. While dopamine …
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …
A perspective on Nrf2 signaling pathway for neuroinflammation: a potential therapeutic target in Alzheimer's and Parkinson's diseases
Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease
(PD), the leading causes of dementia. These neurological disorders are characterized by the …
(PD), the leading causes of dementia. These neurological disorders are characterized by the …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Targeting alpha-synuclein as a therapy for Parkinson's disease
CR Fields, N Bengoa-Vergniory… - Frontiers in molecular …, 2019 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative disorders with a
global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both …
global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both …
Role of Nrf2 in aging, Alzheimer's and other neurodegenerative diseases
M George, M Tharakan, J Culberson, AP Reddy… - Ageing Research …, 2022 - Elsevier
Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
Molecular mechanisms of glutamate toxicity in Parkinson's disease
J Wang, F Wang, D Mai, S Qu - Frontiers in neuroscience, 2020 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease, the pathological
features of which include the presence of Lewy bodies and the neurodegeneration of …
features of which include the presence of Lewy bodies and the neurodegeneration of …
Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight
Mitochondria is one of the main source of oxidative stress (ROS), as it utilizes the oxygen for
the energy production. ROS and RNS are normally generated by tightly regulated enzymes …
the energy production. ROS and RNS are normally generated by tightly regulated enzymes …