[HTML][HTML] Profound properties of protein-rich, platelet-rich plasma matrices as novel, multi-purpose biological platforms in tissue repair, regeneration, and wound …

PA Everts, JF Lana, RW Alexander, I Dallo… - International Journal of …, 2024 - mdpi.com
Autologous platelet-rich plasma (PRP) preparations are prepared at the point of care.
Centrifugation cellular density separation sequesters a fresh unit of blood into three main …

Material matters: exploring the interplay between natural biomaterials and host immune system

AS Tripathi, MEA Zaki, SA Al-Hussain… - Frontiers in …, 2023 - frontiersin.org
Biomaterials are widely used for various medical purposes, for instance, implants, tissue
engineering, medical devices, and drug delivery systems. Natural biomaterials can be …

[HTML][HTML] 3D bioprinting of human neural tissues with functional connectivity

Y Yan, X Li, Y Gao, S Mathivanan, L Kong, Y Tao… - Cell Stem Cell, 2024 - cell.com
Probing how human neural networks operate is hindered by the lack of reliable human
neural tissues amenable to the dynamic functional assessment of neural circuits. We …

Targeted treatment of ischemic and fibrotic complications of myocardial infarction using a dual-delivery microgel therapeutic

E Mihalko, K Huang, E Sproul, K Cheng, AC Brown - ACS nano, 2018 - ACS Publications
Myocardial infarction (MI), commonly known as a heart attack, affects millions of people
worldwide and results in significant death and disabilities. A major cause of MI is fibrin-rich …

Fibrin as a multipurpose physiological platform for bone tissue engineering and targeted delivery of bioactive compounds

B Bujoli, JC Scimeca, E Verron - Pharmaceutics, 2019 - mdpi.com
Although bone graft is still considered as the gold standard method, bone tissue engineering
offers promising alternatives designed to mimic the extracellular matrix (ECM) and to guide …

Clot-Targeted Nanogels for Dual-Delivery of AntithrombinIII and Tissue Plasminogen Activator to Mitigate Disseminated Intravascular Coagulation Complications

A Sheridan, K Nellenbach, S Pandit, E Byrnes… - ACS …, 2024 - ACS Publications
Disseminated intravascular coagulation (DIC) is a pathologic state that follows systemic
injury and other diseases. Often a complication of sepsis or trauma, DIC causes …

Clot structure and implications for bleeding and thrombosis

E Mihalko, AC Brown - Seminars in thrombosis and hemostasis, 2020 - thieme-connect.com
The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound
healing. Fibrin dynamics can become disadvantageous in the formation of aberrant …

Biologic principles of minced cartilage implantation: a narrative review

R Ossendorff, SG Walter, FA Schildberg… - Archives of Orthopaedic …, 2023 - Springer
Cartilage tissue has a very limited ability to regenerate. Symptomatic cartilage lesions are
currently treated by various cartilage repair techniques. Multiple treatment techniques have …

Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

K Nellenbach, A Kyu, N Guzzetta, AC Brown - Blood advances, 2021 - ashpublications.org
Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen,
characterized by increased sialic acid, a greater negative charge, and decreased activity …

Fibrin nanoparticles coupled with keratinocyte growth factor enhance the dermal wound-healing rate

I Muhamed, EP Sproul, FS Ligler… - ACS applied materials & …, 2019 - ACS Publications
Expediting the wound-healing process is critical for patients chronically ill from nonhealing
wounds and diseases such as hemophilia or diabetes or who have suffered trauma …