Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …

Macroautophagy (referred to here as autophagy) degrades and recycles cytoplasmic
constituents to sustain cellular and mammalian metabolism and survival during starvation …

Autophagy captures intracellular components and delivers them to lysosomes, where they
are degraded and recycled to sustain metabolism and to enable survival during starvation …

Highlights•Reviewed the function of arginine and its metabolites in arginine deprivation
therapy.•Discussed the difference of arginine deiminase and recombinant human arginase …

Autophagy is considered a cytoprotective function in cancer therapy under certain conditions
and is a drug resistance mechanism that represents a clinical obstacle to successful cancer …

Background Inhibitors targeting VEGF and VEGFR are commonly used in the clinic, but only
a subset of patients could benefit from these inhibitors and the efficacy was limited by …

Rationale: The circadian clock coordinates cell proliferation and metabolism and impacts the
progression of some diseases, particularly cancer. Pharmacological modulation of the …

Non-small cell lung cancer (NSCLC) is the major cause of cancer-associated death
worldwide, but its underlying mechanisms remain to be fully elucidated. Long noncoding …

Among hundreds of thousands of signal receptors contributing to oncogenic activation,
tumorigenesis, and metastasis, the hepatocyte growth factor (HGF) receptor–also called …

Extensive studies have shown that cancer cells have specific nutrient auxotrophy and thus
have much a higher demand for certain nutrients than normal cells. Amino acid deprivation …