Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep
cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are …

Excessive scars form as a result of aberrations of physiologic wound healing and may arise
following any Insult to the deep dermis. By causing pain, pruritus and contractures …

Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and
Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev. 00032.2002.—Cutaneous …

Following a skin injury, the damaged tissue is repaired through the coordinated biological
actions that constitute the cutaneous healing response. In mammals, repaired skin is not …

Understanding wound healing today involves much more than simply stating that there are
three phases: inflammation, proliferation, and maturation. Wound healing is a complex …

Cardiac fibrosis is a substantial problem in managing multiple forms of heart disease.
Fibrosis results from an unrestrained tissue repair process orchestrated predominantly by …

Abstract Tranilast (N-[3′, 4′-dimethoxycinnamoyl]-anthranilic acid) is an analog of a
tryptophan metabolite. Initially, tranilast was identified as an anti-allergic agent, and used in …

Significance: Wound healing is an intricate biological process in which the skin, or any other
tissue, repairs itself after injury. Normal wound healing relies on the appropriate levels of …

In the liver, the progressive accumulation of connective tissue, a complex and dynamic
process termed fibrosis, represents a very frequent event following a repeated or chronic …

Proper activation of macrophages (Mφ) in the inflammatory phase of acute wound healing is
essential for physiological tissue repair. However, there is a strong indication that robust Mφ …