Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …

Autoimmunity and allergies affect a large number of people across the globe. Current
approaches to these diseases target cell types and pathways that drive disease, but these …

The high prevalence and rising incidence of autoimmune diseases have become a
prominent public health issue. Autoimmune disorders result from the immune system …

Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's
own components, resulting in tissue destruction and organ dysfunction. Autoimmune …

Antigen-specific immunotherapies (ASITs) address important clinical needs in treating
autoimmune diseases. However, Type 1 diabetes is a heterogeneous disease wherein …

Rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1D), and celiac disease
(CD), are strongly associated with susceptible HLA class II haplotypes. The peptide-binding …

Autoimmune diseases are burdensome conditions that affect a significant fraction of the
global population. The hallmark of autoimmune disease is a host's immune system being …

CD73, an important metabolic and immune escape-promoting gene, catalyzes the
hydrolysis of adenosine monophosphate (AMP) to adenosine (ADO). AMP has anti …

Autoantigen-specific immunotherapy using peptides offers a more targeted approach to treat
autoimmune diseases, but clinical implementation has been challenging. We previously …

Islet autoantibodies predict type 1 diabetes (T1D) but can be transient in murine and human
T1D and are not thought to be directly pathogenic. Rather, these autoantibodies signal B cell …