DNA transposons offer an efficient nonviral method of permanently modifying the genomes
of mammalian cells. The piggyBac transposon system has proven effective in genomic …

Transposons derived from Sleeping Beauty (SB), piggyBac (PB), or Tol2 typically require
cotransfection of transposon DNA with a transposase either as an expression plasmid or …

In both humans and mice, repair of acute kidney injury is worse in males than in females.
Here, we provide evidence that this sexual dimorphism results from sex differences in …

Mammalian organs exhibit distinct physiology, disease susceptibility, and injury responses
between the sexes. In the mouse kidney, sexually dimorphic gene activity maps …

Transforming growth factor-β 1 (TGF-β 1) is an important regulator of fibrogenesis in heart
disease. In many other cellular systems, TGF-β 1 may also induce autophagy, but a link …

In damaged kidneys, increased extracellular matrix (ECM) and tissue stiffness stimulate
kidney fibrosis through incompletely characterized molecular mechanisms. The …

Ferroptosis is a recently recognized form of regulated cell death, characterized by iron-
dependent accumulation of lipid peroxidation. Ample evidence has depicted that ferroptosis …

Transposons have emerged as promising vectors for gene therapy that can potentially
overcome some of the limitations of commonly used viral vectors. Transposons stably …

Renal fibrosis is a common feature of chronic kidney disease and is a promising therapeutic
target. However, there is still limited treatment for renal fibrosis, so the development of new …

Abstract Aim Matrix metalloproteinase‐9 (MMP9) plays a profibrotic role in renal fibrosis.
Neutrophils produce MMP9 in many pathologic models. However, the effect of neutrophil on …