This review focuses on recent clinical and translational discoveries in severe and
uncontrolled asthma that now enable phenotyping and personalized therapies in these …

There is current evidence to demonstrate a close association between fungal sensitisation
and asthma severity. Whether such an association is causal remains to be confirmed, but …

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society …

Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Asthma is a global health problem affecting around 300 million individuals of all ages, ethnic
groups and countries. It is estimated that around 250,000 people die prematurely each year …

Rationale: Little is known about vitamin D status and its effect on asthma pathophysiology in
children with severe, therapy-resistant asthma (STRA). Objectives: Relationships between …

Bone marrow stromal cells [BMSCs; also known as mesenchymal stem cells (MSCs)]
effectively suppress inflammatory responses in acute graft-versus-host disease in humans …

Rationale: With the advent of new and expensive therapies for severe refractory asthma,
targeting the appropriate patients is important. An important issue is identifying …

An estimated 300 million people are affected by asthma worldwide and the burden is likely
to rise substantially in the next few decades. Estimates of the prevalence of asthma range …