Enzyme engineering plays a central role in the development of biocatalysts for
biotechnology, chemical and pharmaceutical manufacturing, and environmental …

Atherosclerosis is a leading cause of cardiovascular disease and mortality worldwide.
Alterations in the gut microbiota composition, known as gut dysbiosis, have been shown to …

Rieske oxygenases use a Rieske-type [2Fe-2S] cluster and a mononuclear iron center to
initiate a range of chemical transformations. However, few details exist regarding how this …

Rieske nonheme iron oxygenases use two metallocenters, a Rieske-type [2Fe-2S] cluster
and a mononuclear iron center, to catalyze oxidation reactions on a broad range of …

Rieske oxygenases exploit the reactivity of iron to perform chemically challenging C–H bond
functionalization reactions. Thus far, only a handful of Rieske oxygenases have been …

Trimethylamine-N-oxide (TMAO) is a molecular metabolite derived from the gut flora, which
has recently emerged as a candidate risk factor for metabolic dysfunction-associated fatty …

The trifluoromethyl (− CF3) group represents a highly prevalent functionality in
pharmaceuticals. Over the past few decades, significant advances have been made in the …

Enzymes that depend on sophisticated electron transfer via ferredoxins (Fds) exhibit
outstanding catalytic capabilities, but despite decades of research, many of them are still not …

Oxygenation of aromatic and aliphatic hydrocarbons by Rieske oxygenases is the initial step
of various biodegradation pathways for environmental organic contaminants …

The hydroxylase component (S5HH) of salicylate-5-hydroxylase catalyzes C5 ring
hydroxylation of salicylate but switches to methyl hydroxylation when a C5 methyl …