The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Chronic cough is defined in adults as a cough that lasts for≥ 8 weeks. When it proves
intractable to standard-of-care treatment, it can be referred to as refractory chronic cough …

Background ATP acting via P2X3 receptors is an important mediator of refractory chronic
cough (RCC). This phase 2a double-blinded crossover study assessed the safety …

The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary detector of
environmental cold and an important target for treating pathological cold hypersensitivity …

Pulmonary tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), manifests
with a persistent cough as both a primary symptom and mechanism of transmission. The …

Abstract ATP-dependent P2X3 receptors play a crucial role in the sensitization of nerve
fibers and pathological pain pathways. They are also involved in pathways triggering cough …

Chronic cough, defined as a cough lasting> 8 weeks, is a common medical condition that
exerts a substantial physical, mental, and social burden on patients. A subset of patients with …

The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal
ion channel, activated by low temperatures (< 28° C), pressure, and cooling compounds …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

COVID-19 is described in a clinical case involving a patient who proposed the hypothesis
that Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-interacting nutrients may help to …