[HTML][HTML] Engineering organoids
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …
enormous interest for modelling tissue development and disease, and for personalized …
Organs-on-chips: into the next decade
LA Low, C Mummery, BR Berridge, CP Austin… - Nature Reviews Drug …, 2021 - nature.com
Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …
Tissue geometry drives deterministic organoid patterning
INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …
have enormous potential as models for human organ development and disease, as …
[HTML][HTML] Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
Engineering adeno-associated virus vectors for gene therapy
C Li, RJ Samulski - Nature Reviews Genetics, 2020 - nature.com
Adeno-associated virus (AAV) vector-mediated gene delivery was recently approved for the
treatment of inherited blindness and spinal muscular atrophy, and long-term therapeutic …
treatment of inherited blindness and spinal muscular atrophy, and long-term therapeutic …
[HTML][HTML] Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
Q Sun, Z Hong, C Zhang, L Wang, Z Han… - Signal transduction and …, 2023 - nature.com
Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
Synthetic dynamic hydrogels promote degradation-independent in vitro organogenesis
Epithelial organoids are most efficiently grown from mouse-tumour-derived, reconstituted
extracellular matrix hydrogels, whose poorly defined composition, batch-to-batch variability …
extracellular matrix hydrogels, whose poorly defined composition, batch-to-batch variability …
[HTML][HTML] A materials-science perspective on tackling COVID-19
The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in
providing tools and technologies for antiviral research and treatment development. In this …
providing tools and technologies for antiviral research and treatment development. In this …
[HTML][HTML] Neurological complications and infection mechanism of SARS-COV-2
D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives.
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …