Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved
in different biological processes, such as cell proliferation, angiogenesis, and wound …

Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive
cancer types and the leading cause of cancer-associated deaths. The EMT-inducing …

The YAP transcription coactivator has been implicated as an oncogene and is amplified in
human cancers. Recent studies have established that YAP is phosphorylated and inhibited …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

Taxol (paclitaxel) resistance represents a major challenge in breast cancer treatment. The
TAZ (t ranscriptional co-a ctivator with PD Z-binding motif) oncogene is a major component …

Tumor progression alters the composition and physical properties of the extracellular matrix.
Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis …

Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …

MORC family CW-type zinc finger 2 (MORC2) is a newly identified chromatin-remodeling
enzyme involved in DNA damage response and gene transcription, and its dysregulation …

Uncontrolled transforming growth factor-β (TGFβ) signaling promotes aggressive metastatic
properties in late-stage breast cancers. However, how TGFβ-mediated cues are directed to …