Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity
and mortality among impoverished populations. One hundred years after the discovery of …

Globally, leptospirosis poses an increasing public health problem, as evidenced by
markedly increasing incidence rates and multiple outbreaks in all continents. Yet, the …

Particulate vaccines are emerging promising technologies for the creation of tunable
prophylactics against a wide variety of conditions. Vesicular and solid biodegradable …

Leptospirosis is a neglected infectious disease caused by spirochetes from the genus
Leptospira. It constitutes a major public health problem in developing countries, with …

Leptospira, the causative agent of leptospirosis, interacts with several host molecules,
including extracellular matrix components, coagulation cascade proteins, and human …

The molecular and cellular pathogenesis of leptospirosis remains poorly understood. Based
on comparative bacterial genomics data, we recently identified the hypothetical PF07598 …

Leptospira spp., the causative agents of leptospirosis, adhere to components of the
extracellular matrix, a pivotal role for colonization of host tissues during infection. Previously …

The success of subunit vaccines has been hampered by the problems of weak or short-term
immunity and the lack of availability of nontoxic, potent adjuvants. It would be desirable to …

Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact
on rural and poor urban communities, particularly in developing countries. This has led to …

Leptospirosis is the most widespread zoonosis in the world and a neglected tropical disease
estimated to cause severe infection in more than one million people worldwide every year …