The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

The heat shock transcription factors (HSFs) were discovered over 30 years ago as direct
transcriptional activators of genes regulated by thermal stress, encoding heat shock …

Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein
folding and maturation of a variety of “client” proteins protecting them from degradation …

The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …

The ribosome is a molecular machine responsible for protein synthesis and a major target
for small-molecule inhibitors. Compared to the wealth of structural information available on …

The heat shock response (HSR) was originally discovered as a transcriptional response to
elevated temperature shock and led to the identification of heat shock proteins and heat …

Stromal cells within the tumor microenvironment are essential for tumor progression and
metastasis. Surprisingly little is known about the factors that drive the transcriptional …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill
aneuploid tumour cells and repress translation of specific messenger RNAs,,,. RocA targets …

The cellular proteome is a complex microcosm of structural and regulatory networks that
requires continuous surveillance and modification to meet the dynamic needs of the cell. It is …