Roles of mRNA poly (A) tails in regulation of eukaryotic gene expression

LA Passmore, J Coller - Nature Reviews Molecular Cell Biology, 2022 - nature.com
In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay

JS Mugridge, J Coller, JD Gross - Nature structural & molecular biology, 2018 - nature.com
3′ RNA decay pathways are critical for quality control and regulation of gene expression.
Structural and biochemical studies have provided insights into the key nucleases that carry …

[HTML][HTML] P-body-like condensates in the germline

M Cassani, G Seydoux - Seminars in cell & developmental biology, 2024 - Elsevier
P-bodies are cytoplasmic condensates that accumulate low-translation mRNAs for
temporary storage before translation or degradation. P-bodies have been best characterized …

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

MW Webster, JAW Stowell, LA Passmore - Elife, 2019 - elifesciences.org
The Ccr4-Not complex removes mRNA poly (A) tails to regulate eukaryotic mRNA stability
and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4 …

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

T Raisch, CT Chang, Y Levdansky… - Nature …, 2019 - nature.com
CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene
expression principally via shortening of poly (A) tails of messenger RNA or deadenylation …

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

A Sgromo, T Raisch, P Bawankar, D Bhandari… - Nature …, 2017 - nature.com
Abstract Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA
target degradation through the recruitment of the CCR4-NOT deadenylase complex and are …

The dynamic regulation of mRNA translation and ribosome biogenesis during germ cell development and reproductive aging

M Mercer, S Jang, C Ni, M Buszczak - Frontiers in Cell and …, 2021 - frontiersin.org
The regulation of mRNA translation, both globally and at the level of individual transcripts,
plays a central role in the development and function of germ cells across species. Genetic …

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

CA Weidmann, C Qiu, RM Arvola, TF Lou… - Elife, 2016 - elifesciences.org
Collaboration among the multitude of RNA-binding proteins (RBPs) is ubiquitous, yet our
understanding of these key regulatory complexes has been limited to single RBPs. We …

Evolutionary conservation of the structure and function of meiotic Rec114− Mei4 and Mer2 complexes

D Daccache, E De Jonge, P Liloku… - Genes & …, 2023 - genesdev.cshlp.org
Abstract Meiosis-specific Rec114− Mei4 and Mer2 complexes are thought to enable Spo11-
mediated DNA double-strand break (DSB) formation through a mechanism that involves …

Nanos genes and their role in development and beyond

E De Keuckelaere, P Hulpiau, Y Saeys, G Berx… - Cellular and molecular …, 2018 - Springer
The hallmark of Nanos proteins is their typical (CCHC) 2 zinc finger motif (zf-nanos). Animals
have one to four nanos genes. For example, the fruit fly and demosponge have only one …