Roles of mRNA poly (A) tails in regulation of eukaryotic gene expression
LA Passmore, J Coller - Nature Reviews Molecular Cell Biology, 2022 - nature.com
In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
3′ RNA decay pathways are critical for quality control and regulation of gene expression.
Structural and biochemical studies have provided insights into the key nucleases that carry …
Structural and biochemical studies have provided insights into the key nucleases that carry …
[HTML][HTML] P-body-like condensates in the germline
M Cassani, G Seydoux - Seminars in cell & developmental biology, 2024 - Elsevier
P-bodies are cytoplasmic condensates that accumulate low-translation mRNAs for
temporary storage before translation or degradation. P-bodies have been best characterized …
temporary storage before translation or degradation. P-bodies have been best characterized …
RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not
The Ccr4-Not complex removes mRNA poly (A) tails to regulate eukaryotic mRNA stability
and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4 …
and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4 …
Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene
expression principally via shortening of poly (A) tails of messenger RNA or deadenylation …
expression principally via shortening of poly (A) tails of messenger RNA or deadenylation …
A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
Abstract Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA
target degradation through the recruitment of the CCR4-NOT deadenylase complex and are …
target degradation through the recruitment of the CCR4-NOT deadenylase complex and are …
The dynamic regulation of mRNA translation and ribosome biogenesis during germ cell development and reproductive aging
M Mercer, S Jang, C Ni, M Buszczak - Frontiers in Cell and …, 2021 - frontiersin.org
The regulation of mRNA translation, both globally and at the level of individual transcripts,
plays a central role in the development and function of germ cells across species. Genetic …
plays a central role in the development and function of germ cells across species. Genetic …
Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio
CA Weidmann, C Qiu, RM Arvola, TF Lou… - Elife, 2016 - elifesciences.org
Collaboration among the multitude of RNA-binding proteins (RBPs) is ubiquitous, yet our
understanding of these key regulatory complexes has been limited to single RBPs. We …
understanding of these key regulatory complexes has been limited to single RBPs. We …
Evolutionary conservation of the structure and function of meiotic Rec114− Mei4 and Mer2 complexes
D Daccache, E De Jonge, P Liloku… - Genes & …, 2023 - genesdev.cshlp.org
Abstract Meiosis-specific Rec114− Mei4 and Mer2 complexes are thought to enable Spo11-
mediated DNA double-strand break (DSB) formation through a mechanism that involves …
mediated DNA double-strand break (DSB) formation through a mechanism that involves …
Nanos genes and their role in development and beyond
The hallmark of Nanos proteins is their typical (CCHC) 2 zinc finger motif (zf-nanos). Animals
have one to four nanos genes. For example, the fruit fly and demosponge have only one …
have one to four nanos genes. For example, the fruit fly and demosponge have only one …