Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

S‐adenosyl methionine (SAM) is a universal biological cofactor that is found in all branches
of life where it plays a critical role in the transfer of methyl groups to various biomolecules …

Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …

Covering up to the end of 2011 Many pharmaceuticals on the market today belong to a large
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …

Covering: up to January 2012 The addition of a methyl moiety to a small chemical is a
common transformation in the biosynthesis of natural products across all three domains of …

Glycopeptides such as vancomycin, teicoplanin and telavancin are essential for treating
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …

The nonribosomal peptide synthetases are modular enzymes that catalyze synthesis of
important peptide products from a variety of standard and non-proteinogenic amino acid …

The metabolic differences between B-NHL and primary human B cells are poorly
understood. Among human B-cell non-Hodgkin lymphomas (B-NHL), primary effusion …

Complex peptide natural products exhibit diverse biological functions and a wide range of
physico-chemical properties. As a result, many peptides have entered the clinics for various …

Abstract Nicht‐ribosomale Peptidsynthetasen (NRPSs) sind große Multienzymmaschinerien,
die zahlreiche Peptide mit enormer struktureller und funktionaler Diversität erzeugen. Unter …