Molecular targets of dietary agents for prevention and therapy of cancer

BB Aggarwal, S Shishodia - Biochemical pharmacology, 2006 - Elsevier
While fruits and vegetables are recommended for prevention of cancer and other diseases,
their active ingredients (at the molecular level) and their mechanisms of action less well …

[HTML][HTML] Crucial facts about health benefits of popular cruciferous vegetables

S Manchali, KNC Murthy, BS Patil - Journal of functional foods, 2012 - Elsevier
The lower incidences of many chronic diseases such as cancer and cardiovascular related
ailments are associated with consumption of vegetables rich dietary regimes and this has …

Taste and flavor perceptions of glucosinolates, isothiocyanates, and related compounds

L Bell, OO Oloyede, S Lignou… - Molecular Nutrition & …, 2018 - Wiley Online Library
Brassicaceae plants are renowned for their taste, aroma and trigeminal characteristics;
predominantly bitter taste, sulfurous aroma, and pungency. Compounds responsible for …

Sulforaphane as a promising molecule for fighting cancer

C Fimognari, P Hrelia - Mutation Research/Reviews in Mutation Research, 2007 - Elsevier
A number of natural compounds with inhibitory effects on tumorigenesis have been
identified from our diet. Several studies have documented the cancer-preventive activity of a …

Phytochemical and In Silico ADME/Tox Analysis of Eruca sativa Extract with Antioxidant, Antibacterial and Anticancer Potential against Caco-2 and HCT-116 …

AM Awadelkareem, E Al-Shammari, AEO Elkhalifa… - Molecules, 2022 - mdpi.com
Eruca sativa Mill.(E. sativa) leaves recently grabbed the attention of scientific communities
around the world due to its potent bioactivity. Therefore, the present study investigates the …

Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review

S Khan, KA Awan, MJ Iqbal - Journal of Food biochemistry, 2022 - Wiley Online Library
Sulforaphane belongs to the active class of isothiocyanates capable of delivering various
biological benefits for health promotion and disease prevention. This compound is …

Cancer prevention with promising natural products: mechanisms of action and molecular targets

P Pratheeshkumar, C Sreekala, Z Zhang… - Anti-Cancer Agents …, 2012 - ingentaconnect.com
Cancer is the second leading cause of death worldwide. There is greater need for more
effective and less toxic therapeutic and preventive strategies. Natural products are becoming …

Covalent binding to tubulin by isothiocyanates: a mechanism of cell growth arrest and apoptosis

L Mi, Z Xiao, BL Hood, S Dakshanamurthy… - Journal of Biological …, 2008 - ASBMB
Isothiocyanates (ITCs) found in cruciferous vegetables, including benzyl-ITC (BITC),
phenethyl-ITC (PEITC), and sulforaphane (SFN), inhibit carcinogenesis in animal models …

Antioxidant potential, anti-proliferative activities, and phenolic content in water-soluble fractions of some commonly consumed vegetables: Effects of thermal treatment

MK Roy, M Takenaka, S Isobe, T Tsushida - Food Chemistry, 2007 - Elsevier
Thermal treatments associated with food processing can alter the phenolic content of
vegetables; yet, the biological properties associated with altered phenolic content have not …

Gene expression, cell cycle arrest and MAPK signalling regulation in Caco‐2 cells exposed to ellagic acid and its metabolites, urolithins

A González‐Sarrías, JC Espín… - Molecular nutrition & …, 2009 - Wiley Online Library
Novel gene expression profiles and cellular functions modulated in Caco‐2 cells in
response to the dietary polyphenol, ellagic acid (EA), and its colonic metabolites, urolithin‐A …