Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

In biology as in real estate, location is a cardinal organizational principle that dictates the
accessibility and flow of informational traffic. An essential question in nuclear organization is …

Purpose Given the limited sensitivity and specificity of prostate-specific antigen (PSA), its
widespread use as a screening tool has raised concerns for the overdiagnosis of low-risk …

Abstract Background: Updated National Academy of Clinical Biochemistry (NACB)
Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been …

Prostate cancer is the most prevalent non-skin cancer in men and is the leading cause of
cancer-related death. Early detection of prostate cancer is largely determined by a widely …

Background: Prostate cancer gene 3 (PCA3) encodes a prostate-specific mRNA that has
shown promise as a prostate cancer diagnostic tool. This report describes the …

Purpose: A urinary assay for PCA3, an mRNA that is highly over expressed in prostate
cancer cells, has shown usefulness as a diagnostic test for this common malignancy. We …

Genomes of complex organisms are characterized by the pervasive expression of different
types of noncoding RNAs (ncRNAs). lncRNAs constitute a large family of long—arbitrarily …

OBJECTIVES: Men with elevated serum prostate-specific antigen (PSA) levels and negative
prostate biopsy findings present a dilemma because of the lack of an accurate diagnostic …