Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Since the late 1980s, mutations in the RAS genes have been recognized as major
oncogenes with a high occurrence rate in human cancers. Such mutations reduce the ability …

Molecular glue degraders are small, drug-like compounds that induce interactions between
an E3 ubiquitin ligase and a target, which result in ubiquitination and subsequent …

Direct interactions between proteins are essential for the regulation of their functions in
biological pathways. Targeting the complex network of protein–protein interactions (PPIs) …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

There is now considerable and increasing evidence for a causal role for aberrant activity of
the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP …

Abstract Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only
known target of the alkaloid camptothecin, from which the potent anticancer agents …

Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs)
regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular …

Vinblastine is one of several tubulin-targeting Vinca alkaloids that have been responsible for
many chemotherapeutic successes since their introduction in the clinic as antitumour drugs …