The aim of this review was to consider the effects of induced hypocapnia both on systemic
physiology and on the physiology of the intracranial system. Hyperventilation lowers …

Cerebral autoregulation reflects the ability of the brain to keep the cerebral blood flow (CBF)
relatively constant despite changes in cerebral perfusion pressure. It is an intrinsic …

The glymphatic pathway expedites clearance of waste, including soluble amyloid β (Aβ)
from the brain. Transport through this pathway is controlled by the brain9s arousal level …

Object Cerebral ischemia is the leading cause of preventable death in cases of major
trauma with severe traumatic brain injury (TBI). Intracranial pressure (ICP) control and …

Background: An increase in mortality has been documented in association with paramedic
rapid sequence intubation (RSI) of severely head-injured patients. This analysis explores …

Background: Although early intubation to prevent the mortality that accompanies hypoxia is
considered the standard of care for severe traumatic brain injury (TBI), the efficacy of this …

Objective: To determine a) whether packed red blood cell transfusion (RBCT) increases
local brain tissue oxygen partial pressure (Pbto 2) in a neurocritical care population; and b) …

Objectives: An increase in mortality has been reported with early intubation in severe
traumatic brain injury, possibly due to suboptimal ventilation. This analysis explores the …

This publication contains the pediatric and neonatal sections of the 2005 International
Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care …

Object. Hyperventilation therapy, blood pressure augmentation, and metabolic suppression
therapy are often used to reduce intracranial pressure (ICP) and improve cerebral perfusion …