A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Erythroblasts possess unique characteristics as they undergo differentiation from
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …

Chicken erythrocytes are nucleated cells often considered to be transcriptionally inactive,
although the epigenetic changes and chromatin remodeling that would mediate …

Signaling by the TGF-β superfamily is important in the regulation of hematopoiesis and is
dysregulated in myelodysplastic syndromes (MDSs), contributing to ineffective …

Murine-based cellular models have provided and continue to provide many useful insights
into the fundamental mechanisms of erythropoiesis, as well as insights into the …

Mammalian red blood cells lack nuclei. The molecular mechanisms underlying erythroblast
nuclear condensation and enucleation, however, remain poorly understood. Here we show …

Erythropoiesis is a process of enormous magnitude, with the average person generating two
to three million red cells every second. Erythroid progenitors start as large cells with large …

Background Condensation of chromatin prior to enucleation is an essential component of
terminal erythroid maturation, and defects in this process are associated with inefficient …

Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase of polycomb repressive
complex 2 (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of …

The selenoprotein glutathione peroxidase 4 (GPX4), the only member of the glutathione
peroxidase family able to directly reduce cell membrane–oxidized fatty acids and …