A future blood test to detect cerebral aneurysms

KW Nowicki, AM Mittal, H Abou-Al-Shaar… - Cellular and Molecular …, 2023 - Springer
Intracranial aneurysms are reported to affect 2–5% of the population. Despite advances in
the surgical management of this disease, diagnostic technologies have marginally improved …

Circular RNA hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement

XB Wu, YT Wu, XX Guo, C Xiang, PS Chen… - Frontiers in …, 2022 - frontiersin.org
Background Circular RNAs (circRNAs) may involve the formation and rupture of intracranial
aneurysms (IA). Inflammation plays a vital role in the development and progression of IA …

Transcriptomic studies on intracranial aneurysms

R Morga, J Pera - Genes, 2023 - mdpi.com
Intracranial aneurysm (IA) is a relatively common vascular malformation of an intracranial
artery. In most cases, its presence is asymptomatic, but IA rupture causing subarachnoid …

Profiling of circulating gene expression reveals molecular signatures associated with intracranial aneurysm rupture risk

KE Poppenberg, A Chien, BA Santo, L Chaves… - Molecular diagnosis & …, 2023 - Springer
Background Following detection, rupture risk assessment for intracranial aneurysms (IAs) is
critical. Towards molecular prognostics, we hypothesized that circulating blood RNA …

RNA expression signatures of intracranial aneurysm growth trajectory identified in circulating whole blood

KE Poppenberg, A Chien, BA Santo, AA Baig… - Journal of Personalized …, 2023 - mdpi.com
After detection, identifying which intracranial aneurysms (IAs) will rupture is imperative. We
hypothesized that RNA expression in circulating blood reflects IA growth rate as a surrogate …

Neutrophil-to-lymphocyte ratio is associated with circumferential wall enhancement of unruptured intracranial aneurysm

XB Wu, JL Zhong, SW Wang, Y Su, PS Chen… - Frontiers in …, 2022 - frontiersin.org
Background and Purpose Neutrophil-lymphocyte ratio (NLR) predicts clinical outcomes in
patients with stroke. Aneurysm wall enhancement (AWE) on high-resolution vessel wall …

Study the local metabolic changes of aneurysms through microcatheter sampling

Z Li, T Zhang, Y Feng, Y Ma, H Chen, X Wu, J Chen… - Scientific Reports, 2024 - nature.com
Intracranial aneurysm is the primary cause of nontraumatic subarachnoid hemorrhage. To
assess aneurysm metabolism, we present a method of intra-operatively collecting blood …

[HTML][HTML] A prospective diagnostic and prognostic biomarker for hepatocellular carcinoma that functions in glucose metabolism regulation: Solute carrier family 37 …

Z Meng, X Geng, X Lin, Z Wang, D Chen… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Due to the
insidious onset of HCC, early diagnosis is relatively difficult. HCC also exhibit strong …

Causal association between circulating inflammatory cytokines and intracranial aneurysm and subarachnoid hemorrhage

Q He, W Wang, Y Xiong, C Tao, L Ma… - European Journal of …, 2024 - Wiley Online Library
Background and purpose The causal association between inflammatory cytokines and the
development of intracranial aneurysm (IA), unruptured IA (uIA) and subarachnoid …

Immunological alterations in intracranial aneurysm: a prospective study on selected biomarker profiles in blood collected during endovascular neurointervention

K Bartnik, J Żyłkowski, J Giziński… - Neurologia i …, 2024 - journals.viamedica.pl
Introduction. Previous studies showed that the concentrations of selected chemokines are
locally elevated in samples collected from the lumen of intracranial aneurysms (IA). Our …