Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

Methicillin-resistant Staphylococcus aureus (MRSA) is the most common pathogen both in
hospital and community settings, and is capable of causing serious and even fatal infections …

Neisseria gonorrhoeae represents an urgent public health threat due to the rapid
emergence of resistance to current antibiotics and the limited number of anti-gonococcal …

Rapid emergence of multidrug resistant Staphylococcus aureus infections has created a
critical health menace universally. Resistance to all the available chemotherapeutics has …

Candida species are a leading source of healthcare infections globally. The limited number
of antifungal drugs combined with the isolation of Candida species, namely C. albicans and …

The narrow antibacterial spectrum of phenylthiazole antibiotics was expanded by replacing
central thiazole with a pyrazole ring while maintaining its other pharmacophoric features …

Methicillin-resistant Staphylococcus aureus (MRSA) infections are a significant burden both
clinically and economically worldwide. Increasing resistance to current antibiotics requires …

A set of structurally related diphenylurea derivatives bearing aminoguanidine moiety were
synthesized, and their antibacterial activity was assessed against a panel of multi-drug …

Based on a structure-guided approach, aryl sulfonyl hydrazones conjugated with 1, 3-diaryl
pyrazoles were designed to target metallo-β-lactamases (MBLs), using Klebsiella …