The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Inflammatory signals induce feedback and feedforward systems that provide temporal
control. Although glucocorticoids can repress inflammatory gene expression, glucocorticoid …

Corticosteroids (CSs) are commonly used to manage wheezing and asthma in pediatric
populations. Although corticosteroids are effective in alleviating airway diseases, some …

Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the
pathogenesis of many inflammatory disorders, including those of the lung such as cystic …

In depression, continual activation of the hypothalamic–pituitaryadrenal (HPA) axis with
excess cortisol release leads to impair sensitivity of the glucocorticoid receptor (GR) and …

Glucocorticoid drugs are commonly used in the treatment of several conditions, including
autoimmune diseases, asthma and cancer. Despite their widespread use and knowledge of …

Asthma is a complex pulmonary disorder with multiple pathological mechanisms. A key
pathological feature of chronic asthma is airway remodeling, which is largely attributed to …

Regulation of cellular catabolic metabolism in immune cells has recently become a major
concept for resolution of inflammation. Nuclear receptors (NRs), including peroxisome …

The glucocorticoid receptor (NR3C1, also known as GR) binds to specific DNA sequences
and directly induces transcription of anti-inflammatory genes that contribute to cytokine …