The emerging problem of linezolid-resistant Staphylococcus

B Gu, T Kelesidis, S Tsiodras, J Hindler… - Journal of …, 2013 - academic.oup.com
The oxazolidinone antibiotic linezolid has demonstrated potent antimicrobial activity against
Gram-positive bacterial pathogens, including methicillin-resistant staphylococci. This article …

Eight-year (2002-2009) Summary of the Linezolid (Zyvox® Annual Appraisal of potency and Spectrum; ZAAPS) Program in European Countries

JE Ross, DJ Farrell, RE Mendes, HS Sader… - Journal of …, 2011 - Taylor & Francis
The linezolid surveillance network (ZAAPS program) has been monitoring linezolid activity
and susceptibility rates for eight years (2002-2009) in European medical centers. Samples …

Molecular epidemiology of Staphylococcus epidermidis clinical isolates from US hospitals

RE Mendes, LM Deshpande, AJ Costello… - Antimicrobial agents …, 2012 - Am Soc Microbiol
The epidemiology of Staphylococcus epidermidis in US hospitals remains limited. This study
aimed to address the genetic backgrounds of linezolid-susceptible and-resistant S …

Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms

H Chen, W Wu, M Ni, Y Liu, J Zhang, F Xia… - International journal of …, 2013 - Elsevier
Genetic characterisation of linezolid-resistant Gram-positive cocci in a multicentre study in
China has not been reported previously. To study the mechanism underlying the resistance …

Long-lasting successful dissemination of resistance to oxazolidinones in MDR Staphylococcus epidermidis clinical isolates in a tertiary care hospital in France

L Dortet, P Glaser, N Kassis-Chikhani… - Journal of …, 2018 - academic.oup.com
Objectives Patient-and procedure-related changes in modern medicine have turned CoNS
into one of the major nosocomial pathogens. Treatments of CoNS infections are challenging …

An international activity and spectrum analysis of linezolid: ZAAPS Program results for 2011

RK Flamm, RE Mendes, JE Ross, HS Sader… - … and Infectious Disease, 2013 - Elsevier
Through a continuing resistance surveillance monitoring program, linezolid was shown to
maintain its spectrum and potency against a collection of 8059 clinically relevant Gram …

Coagulase-negative staphylococcal bloodstream and prosthetic-device-associated infections: the role of biofilm formation and distribution of adhesin and toxin genes

N Giormezis, F Kolonitsiou, A Foka… - Journal of medical …, 2014 - microbiologyresearch.org
Coagulase-negative staphylococci (CNS), especially Staphylococcus epidermidis and
Staphylococcus haemolyticus, have emerged as opportunistic pathogens in …

Characterization and monitoring of linezolid-resistant clinical isolates of Staphylococcus epidermidis in an intensive care unit 4 years after an outbreak of infection by …

E Baos, FJ Candel, P Merino, I Pena… - … microbiology and infectious …, 2013 - Elsevier
Resistance to linezolid is emerging among Staphylococcus epidermidis isolates. During the
4 years following an outbreak of cfr-mediated linezolid-resistant S. aureus in our intensive …

Nosocomial outbreak of methicillin-and linezolid-resistant Staphylococcus epidermidis associated with catheter-related infections in intensive care unit patients

C Seral, Y Sáenz, S Algarate, E Duran, P Luque… - International Journal of …, 2011 - Elsevier
A total of 128 isolates associated with catheter-related infections was recovered from 101
intensive care unit patients in a Spanish hospital during March 2008 to August 2009, and 27 …

Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing

R Tewhey, B Gu, T Kelesidis, C Charlton, A Bobenchik… - MBio, 2014 - Am Soc Microbiol
Linezolid resistance is uncommon among staphylococci, but approximately 2% of clinical
isolates of coagulase-negative staphylococci (CoNS) may exhibit resistance to linezolid …