Tick saliva has been extensively studied in the context of tick-host interactions because it is
involved in host homeostasis modulation and microbial pathogen transmission to the host …

The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …

The degree to which evolution is predictable is a fundamental question in biology. Previous
attempts to predict the evolution of protein sequences have been limited to specific proteins …

Signal perception is a key function in regulating biological activities and adapting to
changing environments. Per-Arnt-Sim (PAS) domains are ubiquitous sensors found in …

Ribonucleotide reductases (RNRs) are used by all free-living organisms and many viruses
to catalyze an essential step in the de novo biosynthesis of DNA precursors. RNRs are …

The tendency for proteins to form aggregates is an inherent part of every proteome and
arises from the self-assembly of short protein segments called aggregation-prone regions …

Alkaloids are important bioactive molecules throughout the natural world, and in many
animals they serve as a source of chemical defense against predation. Dendrobatid poison …

Objective Due to the increasing prevalence of obesity and insulin resistance, there is an
urgent need for better treatment of obesity and its related metabolic disorders. This study …

Serpins are widely distributed and functionally diverse inhibitors of serine proteases. Ticks
secrete serpins with anti-coagulation, anti-inflammatory, and immunomodulatory activities …

Motivation Protein sequence alignments are essential to structural, evolutionary and
functional analysis, but their accuracy is often limited by sequence similarity unless …