The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …

Calcium is a versatile and dynamic 2nd messenger that is essential for the survival of all
higher organisms. In cells that undergo activation or excitation, calcium is released from the …

Each normal organ and pathological condition appear to contain organ-or disease-specific
molecular tags on its vasculature, which constitute a vascular “zip code” system. In vivo …

Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death
characterized by reactive oxygen species (ROS) generation and lipid peroxidation. Here, we …

Nature's way for bioactive peptides is to provide them with several related functions and the
ability to cooperate in performing their job. Natural cell-penetrating peptides (CPP), such as …

Extracellular vesicles (EVs) are nano‐sized membranous structures involved in intercellular
communication and various physiological and pathological processes. Here, we present a …

Mitochondria are a key pharmacological target in all cancer cells, since the structure and
function of this organelle is different between healthy and malignant cells. Oxidative …

Cancer is one of the leading causes of mortality worldwide, with more than 10 million new
cases each year. Despite the presence of several anticancer agents, cancer treatment is still …

Bacterial cancer therapy relies on the fact that several bacterial species are capable of
targeting tumor tissue and that bacteria can be genetically engineered to selectively deliver …