Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides
presented by the major histocompatibility complex (pMHC) on the surface of professional …

Prophylactic vaccination constitutes one of the most prominent medical achievements of
history. This concept was first demonstrated by the pioneer work of Edward Jenner, dating …

Clonotype analysis is essential for complete characterization of antigen-specific T cells.
Moreover, knowledge on clonal identity allows tracking of antigen-specific T cells in whole …

Despite the success of immunotherapy using checkpoint blockade, many patients with solid
tumors remain refractory to these treatments. In human cancer, the experimental options to …

Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor
(TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated …

Despite influencing many aspects of T cell biology, the kinetics of T cell receptor (TCR)
binding to peptide-major histocompatibility molecules (pMHC) remain infrequently …

Aberrant immune responses characterize autoimmune disorders like Rheumatoid Arthritis
(RA) wherein lymphocytes are recognized as key players. Role of CD8+ T cells in RA has …

Cytotoxic CD8 T cells mediate immunity to pathogens and they are able to eliminate
malignant cells. Immunity to viruses and bacteria primarily involves CD8 T cells bearing high …

CD8 T-cell response efficiency critically depends on the TCR binding strength to peptide-
MHC, ie, the TCR binding avidity. A current challenge in onco-immunology lies in the …

Purpose: Patients with cancer benefit increasingly from T-cell–based therapies, such as
adoptive T-cell transfer, checkpoint blockade, or vaccination. We have previously shown that …