BCMA-targeted immunotherapy for multiple myeloma

B Yu, T Jiang, D Liu - Journal of hematology & oncology, 2020 - Springer
B cell maturation antigen (BCMA) is a novel treatment target for multiple myeloma (MM) due
to its highly selective expression in malignant plasma cells (PCs). Multiple BCMA-targeted …

Targeting B cell maturation antigen (BCMA) in multiple myeloma: potential uses of BCMA-based immunotherapy

SF Cho, KC Anderson, YT Tai - Frontiers in immunology, 2018 - frontiersin.org
The approval of the first two monoclonal antibodies targeting CD38 (daratumumab) and
SLAMF7 (elotuzumab) in late 2015 for treating relapsed and refractory multiple myeloma …

[HTML][HTML] A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

S Li, Q Jiang, S Liu, Y Zhang, Y Tian, C Song… - Nature …, 2018 - nature.com
Nanoscale robots have potential as intelligent drug delivery systems that respond to
molecular triggers,,,. Using DNA origami we constructed an autonomous DNA robot …

T cells genetically modified to express an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of poor-prognosis relapsed multiple myeloma

JN Brudno, I Maric, SD Hartman, JJ Rose… - Journal of Clinical …, 2018 - ascopubs.org
Purpose Therapies with novel mechanisms of action are needed for multiple myeloma (MM).
T cells can be genetically modified to express chimeric antigen receptors (CARs), which are …

γ-Secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma

MJ Pont, T Hill, GO Cole, JJ Abbott… - Blood, The Journal …, 2019 - ashpublications.org
B-cell maturation antigen (BCMA) is a validated target for chimeric antigen receptor (CAR) T-
cell therapy in multiple myeloma (MM). Despite promising objective response rates, most …

Efficacy and safety of subcutaneous belimumab in systemic lupus erythematosus: a fifty‐two–week randomized, double‐blind, placebo‐controlled study

W Stohl, A Schwarting, M Okada… - Arthritis & …, 2017 - Wiley Online Library
Objective To assess the efficacy and safety of subcutaneous (SC) belimumab in patients
with systemic lupus erythematosus (SLE). Methods Patients with moderate‐to‐severe SLE …

Management of immunotherapy-related toxicities, version 1.2022, NCCN clinical practice guidelines in oncology

JA Thompson, BJ Schneider, J Brahmer… - Journal of the National …, 2022 - jnccn.org
The aim of the NCCN Guidelines for Management of Immunotherapy-Related Toxicities is to
provide guidance on the management of immune-related adverse events resulting from …

B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma

RO Carpenter, MO Evbuomwan, S Pittaluga… - Clinical cancer …, 2013 - AACR
Purpose: Multiple myeloma is a usually incurable malignancy of plasma cells. New
therapies are urgently needed for multiple myeloma. Adoptive transfer of chimeric antigen …

Bispecific antibodies in multiple myeloma: present and future

G Lancman, DL Sastow, HJ Cho, S Jagannath… - Blood cancer …, 2021 - AACR
Despite many recent advances in therapy, there is still no plateau in overall survival curves
in multiple myeloma. Bispecific antibodies are a novel immunotherapeutic approach …

Teclistamab is an active T cell–redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma

K Pillarisetti, G Powers, L Luistro, A Babich… - Blood …, 2020 - ashpublications.org
B-cell maturation antigen (BCMA), a member of the tumor necrosis factor family of receptors,
is predominantly expressed on the surface of terminally differentiated B cells. BCMA is …