Lifestyle and host determinants of antitumor immunity and cancer health disparities

A Swaby, A Atallah, O Varol, A Cristea, DF Quail - Trends in Cancer, 2023 - cell.com
Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …

NETosis: sculpting tumor metastasis and immunotherapy

Y Hu, H Wang, Y Liu - Immunological Reviews, 2024 - Wiley Online Library
The process of neutrophil extracellular traps (NETs) formation, called NETosis, is a peculiar
death modality of neutrophils, which was first observed as an immune response against …

Mechanisms by which Obesity Regulates Inflammation and Anti-tumor Immunity in Cancer.

CE Maracle, CL McCallister, RD Egelton… - Biochemical and …, 2024 - Elsevier
Obesity is associated with an increased risk for 13 different cancers. The increased risk for
cancer in obesity is mediated by obesity-associated changes in the immune system. Obesity …

Linking adiposity to interstitial lung disease: the role of the dysfunctional adipocyte and inflammation

M Macklin, C Thompson, L Kawano-Dourado… - Cells, 2023 - mdpi.com
Adipose tissue has functions beyond its principal functions in energy storage, including
endocrine and immune functions. When faced with a surplus of energy, the functions of …

Macrophages and T cells in metabolic disorder-associated cancers

D Taranto, DJ Kloosterman, L Akkari - Nature Reviews Cancer, 2024 - nature.com
Cancer and metabolic disorders have emerged as major global health challenges, reaching
epidemic levels in recent decades. Often viewed as separate issues, metabolic disorders …

The m6A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia

X Wu, H Liu, J Wang, S Zhang, Q Hu, T Wang… - Cell Death & …, 2024 - nature.com
Persistent neuroinflammation and progressive neuronal loss are defining features of acute
brain injury including traumatic brain injury (TBI) and cerebral stroke. Microglia, the most …

Association between obesity and systemic immune inflammation index, systemic inflammation response index among US adults: a population-based analysis

Y Zhou, Y Wang, T Wu, A Zhang, Y Li - Lipids in Health and Disease, 2024 - Springer
Background Obesity is characterized by a chronic low-grade inflammatory condition. Two
emerging inflammatory biomarkers, the systemic immune-inflammation index (SII) and the …

Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity

V Radushev, I Karkossa, J Berg, M Von Bergen… - Frontiers in …, 2024 - frontiersin.org
Introduction Obesity is associated with a plethora of health complications, including
increased susceptibility to infections or decreased vaccine efficacy, partly due to …

Obesity, bone marrow adiposity, and leukemia: Time to act

V Kumar, JH Stewart IV - Obesity Reviews, 2024 - Wiley Online Library
Obesity has taken the face of a pandemic with less direct concern among the general
population and scientific community. However, obesity is considered a low‐grade systemic …

Not just sugar: metabolic control of neutrophil development and effector functions

P Ettel, T Weichhart - Journal of Leukocyte Biology, 2024 - academic.oup.com
The mammalian immune system is constantly surveying our tissues to clear pathogens and
maintain tissue homeostasis. In order to fulfill these tasks, immune cells take up nutrients to …