Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
Oxysterols: From cholesterol metabolites to key mediators
V Mutemberezi, O Guillemot-Legris… - Progress in lipid research, 2016 - Elsevier
Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …
Target identification among known drugs by deep learning from heterogeneous networks
Without foreknowledge of the complete drug target information, development of promising
and affordable approaches for effective treatment of human diseases is challenging. Here …
and affordable approaches for effective treatment of human diseases is challenging. Here …
The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV …
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV …
Targeting Th17 cells in autoimmune diseases
J Yang, MS Sundrud, J Skepner, T Yamagata - Trends in pharmacological …, 2014 - cell.com
T helper 17 (Th17) cells have been implicated in the pathogenesis of most common
autoimmune diseases, including psoriasis, rheumatoid arthritis (RA), inflammatory bowel …
autoimmune diseases, including psoriasis, rheumatoid arthritis (RA), inflammatory bowel …
Dosing-time makes the poison: circadian regulation and pharmacotherapy
R Dallmann, A Okyar, F Lévi - Trends in molecular medicine, 2016 - cell.com
Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
Nuclear receptors and their selective pharmacologic modulators
Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Chronopharmacology: new insights and therapeutic implications
Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …