Molecular regulations of circadian rhythm and implications for physiology and diseases

F Fagiani, D Di Marino, A Romagnoli… - Signal transduction and …, 2022 - nature.com
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

Oxysterols: From cholesterol metabolites to key mediators

V Mutemberezi, O Guillemot-Legris… - Progress in lipid research, 2016 - Elsevier
Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Target identification among known drugs by deep learning from heterogeneous networks

X Zeng, S Zhu, W Lu, Z Liu, J Huang, Y Zhou… - Chemical …, 2020 - pubs.rsc.org
Without foreknowledge of the complete drug target information, development of promising
and affordable approaches for effective treatment of human diseases is challenging. Here …

The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome

B He, K Nohara, N Park, YS Park, B Guillory, Z Zhao… - Cell metabolism, 2016 - cell.com
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

LA Solt, Y Wang, S Banerjee, T Hughes, DJ Kojetin… - Nature, 2012 - nature.com
Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV …

Targeting Th17 cells in autoimmune diseases

J Yang, MS Sundrud, J Skepner, T Yamagata - Trends in pharmacological …, 2014 - cell.com
T helper 17 (Th17) cells have been implicated in the pathogenesis of most common
autoimmune diseases, including psoriasis, rheumatoid arthritis (RA), inflammatory bowel …

Dosing-time makes the poison: circadian regulation and pharmacotherapy

R Dallmann, A Okyar, F Lévi - Trends in molecular medicine, 2016 - cell.com
Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

Nuclear receptors and their selective pharmacologic modulators

TP Burris, LA Solt, Y Wang, C Crumbley… - Pharmacological …, 2013 - ASPET
Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …

International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023

TP Burris, IMS de Vera, I Cote, CA Flaveny… - Pharmacological …, 2023 - ASPET
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Chronopharmacology: new insights and therapeutic implications

R Dallmann, SA Brown, F Gachon - Annual review of …, 2014 - annualreviews.org
Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …