Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury

LL Wang, Y Liu, JJ Chung, T Wang, AC Gaffey… - Nature biomedical …, 2017 - nature.com
MicroRNA-based therapies that target cardiomyocyte proliferation have great potential for
the treatment of myocardial infarction. In previous work, we showed that the miR-302/367 …

[HTML][HTML] Stem-cell therapy for cardiac disease

VFM Segers, RT Lee - Nature, 2008 - nature.com
Heart failure is the leading cause of death worldwide, and current therapies only delay
progression of the disease. Laboratory experiments and recent clinical trials suggest that …

The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation

P Menasché, O Alfieri, S Janssens, W McKenna… - Circulation, 2008 - Am Heart Assoc
Background—Phase I clinical studies have demonstrated the feasibility of implanting
autologous skeletal myoblasts in postinfarction scars. However, they have failed to …

Stem cell therapy: a new therapeutic option for cardiovascular diseases

NH Goradel, FG Hour, B Negahdari… - Journal of cellular …, 2018 - Wiley Online Library
Cardiovascular diseases are known as one of major causes of morbidity and mortality
worldwide. Despite the many advancement in therapies are associated with cardiovascular …

Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types

E Cambria, FS Pasqualini, P Wolint, J Günter… - NPJ Regenerative …, 2017 - nature.com
Acute myocardial infarction and chronic heart failure rank among the major causes of
morbidity and mortality worldwide. Except for heart transplantation, current therapy options …

Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction

M Mazo, V Planat‐Bénard, G Abizanda… - European journal of …, 2008 - Wiley Online Library
Aims: To determine the effect of transplantation of undifferentiated and cardiac pre‐
differentiated adipose stem cells compared with bone marrow mononuclear cells (BM‐MNC) …

Mending a broken heart: current strategies and limitations of cell-based therapy

LC Liew, BX Ho, BS Soh - Stem Cell Research & Therapy, 2020 - Springer
The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity
and plasticity, has sparked a considerable interest for potential application in regenerative …

Update on therapeutic vascularization strategies

EA Phelps, AJ Garcia - Regenerative medicine, 2009 - Taylor & Francis
The ability to exploit angiogenesis and vascularization as a therapeutic strategy will be of
enormous benefit to a wide range of medical and tissue-engineering applications …