Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding
enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to …

Initiating and maintaining optimal immune responses requires high levels of protein
synthesis, folding, modification and trafficking in leukocytes, which are processes …

Plasmacytoid dendritic cells (pDCs) chronically produce type I interferon (IFN-I) in
autoimmune diseases, including systemic sclerosis (SSc) and systemic lupus erythematosus …

The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Group 3 innate lymphoid cells (ILC3s) are key players in intestinal homeostasis. ER stress is
linked to inflammatory bowel disease (IBD). Here, we used cell culture, mouse models, and …

Abstract Background Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum
(ER) is crucial for proper Ca2+ signaling and key cellular functions. Although Ca2+ …

Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease
(MASLD), harmful use of alcohol, or viral hepatitis, may result in liver fibrosis, cirrhosis, and …

Despite the high prevalence of osteoarthritis (OA) in older populations, disease-modifying
OA drugs (DMOADs) are still lacking. This study was performed to investigate the effects and …

The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the
protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein …

Mitochondrial diseases are a group of disorders defined by defects in oxidative
phosphorylation caused by nuclear‐or mitochondrial‐encoded gene mutations. A main …