Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional
remodeling in response to injury, disease, or infection of the CNS. Although this remodeling …

The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies
examining plaque-associated proteins have shown these additional proteins are important; …

Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely
overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an …

Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

Vimentin is a protein that has been linked to a large variety of pathophysiological conditions,
including cataracts, Crohn's disease, rheumatoid arthritis, HIV and cancer. Vimentin has also …

Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …

Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Rapidly progressive Alzheimer's disease (rpAD) is a particularly aggressive form of
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …

Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP
splice isoforms show differential expression patterns in the human brain. GFAPδ is …