Oxidative stress in human pathology and aging: molecular mechanisms and perspectives
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
Mechanisms of mitochondrial respiratory adaptation
CF Bennett, P Latorre-Muro, P Puigserver - Nature Reviews Molecular …, 2022 - nature.com
Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …
maintain cell and organismal fitness and survival in the changing environment by adjusting …
The cell biology of mitochondrial membrane dynamics
M Giacomello, A Pyakurel, C Glytsou… - Nature reviews Molecular …, 2020 - nature.com
Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …
mitochondria are often considered the 'powerhouses of the cell'. However, our …
RONS and oxidative stress: An overview of basic concepts
AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
The functional universe of membrane contact sites
WA Prinz, A Toulmay, T Balla - Nature reviews Molecular cell biology, 2020 - nature.com
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …
environmental and developmental changes. One way in which organelles communicate and …
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Chronic inflammation triggers compensatory immunosuppression to stop inflammation and
minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress …
minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress …
Endoplasmic reticulum stress signalling–from basic mechanisms to clinical applications
A Almanza, A Carlesso, C Chintha… - The FEBS …, 2019 - Wiley Online Library
The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …
compartment of the secretory pathway. As such, the ER contributes to the production and …
The functional impact of mitochondrial structure across subcellular scales
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …
mitochondria varies from cell to cell depending on the relative demands for energy …
Endoplasmic reticulum–mitochondrial contactology: structure and signaling functions
G Csordás, D Weaver, G Hajnóczky - Trends in cell biology, 2018 - cell.com
Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …
behavior. These contacts, which typically involve a small fraction of the endomembrane …