Relevant human tissue resources and laboratory models for use in endometriosis research

E Greaves, HOD Critchley, AW Horne… - Acta Obstetricia et …, 2017 - Wiley Online Library
Endometriosis is characterized by the growth of endometrium‐like tissue outside the uterus,
most commonly on the pelvic peritoneum and ovaries. Although it may be asymptomatic in …

Nerve fibers and endometriotic lesions: partners in crime in inflicting pains in women with endometriosis

D Yan, X Liu, SW Guo - European Journal of Obstetrics & Gynecology and …, 2017 - Elsevier
One of major objectives in treating endometriosis is to alleviate pain since dysmenorrhea
and other types of pain top the list of complaints from women with endometriosis who seek …

Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model

Y Liu, X Qin, X Lu, J Jiang - Canadian journal of physiology and …, 2019 - cdnsciencepub.com
This study investigated the relationship between the pain of sciatic endometriosis and the
phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin …

Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for …

P Nunez-Badinez, B De Leo, A Laux-Biehlmann… - Pain, 2021 - journals.lww.com
Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic
pain conditions for which better treatments are urgently needed. Development of new …

Fractalkine/CX3CR1 contributes to endometriosis-induced neuropathic pain and mechanical hypersensitivity in rats

Z Liu, S Chen, C Qiu, Y Sun, W Li, J Jiang… - Frontiers in cellular …, 2018 - frontiersin.org
Pain is the most severe and common symptom of endometriosis. Its underlying pathogenetic
mechanism is poorly understood. Nerve sensitization is a particular research challenge, due …

Perineural invasion in endometriotic lesions contributes to endometriosis-associated pain

Y Liang, D Liu, F Yang, W Pan, F Zeng, J Wu… - Journal of Pain …, 2018 - Taylor & Francis
Purpose Recent studies have shown that abnormal distribution of pelvic nerves contributes
to endometriosis-associated pain. However, the relationship between neurogenesis and …

Anti-nociceptive and anti-inflammatory effects of sulforaphane on sciatic endometriosis in a rat model

Y Liu, Z Zhang, X Lu, J Meng, X Qin, J Jiang - Neuroscience Letters, 2020 - Elsevier
Endometriosis of sciatic nerve is a common gynecological disease. Here we aimed to study
the anti-inflammatory and anti-nociceptive role of sulforaphane on sciatic nerve …

Identification of early symptoms of endometriosis through the analysis of online social networks: A social media study

M Fruchart, F El Idrissi, A Lamer, K Belarbi… - Digital …, 2023 - journals.sagepub.com
Objective Endometriosis is a complex full-body inflammation disease with an average time
to diagnosis of 7–10 years. Social networks give opportunity to patient to openly discuss …

Endometriosis-associated pain–do preclinical rodent models provide a good platform for translation?

E Greaves, M Rosser, PTK Saunders - Animal Models for Endometriosis …, 2020 - Springer
Pelvic pain is a common symptom of endometriosis. Our understanding of its etiology
remains incomplete and medical management is limited by poor translation from preclinical …

Behavioural and neural responses to aversive visceral stimuli in women with primary dysmenorrhoea

B Böttcher, ER Gizewski, C Siedentopf… - … Journal of Pain, 2019 - Wiley Online Library
Background Chronic pelvic pain, in particular dysmenorrhoea, is a significant yet unresolved
healthcare problem in gynaecology. As interoceptive sensitivity and underlying neural …