[HTML][HTML] Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis

LA Beck, MJ Cork, M Amagai, A De Benedetto… - JID Innovations, 2022 - Elsevier
Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented?

HA Brough, KC Nadeau, SB Sindher, SS Alkotob… - Allergy, 2020 - Wiley Online Library
There is increasing evidence regarding the importance of allergic sensitization through the
skin. In this review, we provide an overview of the atopic march and immune mechanism …

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

JR Chalmers, RH Haines, LE Bradshaw… - The Lancet, 2020 - thelancet.com
Background Skin barrier dysfunction precedes eczema development. We tested whether
daily use of emollient in the first year could prevent eczema in high-risk children. Methods …

[PDF][PDF] Significance of skin barrier dysfunction in atopic dermatitis

BE Kim, DYM Leung - Allergy, asthma & immunology …, 2018 - synapse.koreamed.org
The epidermis contains epithelial cells, immune cells, and microbes which provides a
physical and functional barrier to the protection of human skin. It plays critical roles in …

Atopic dermatitis: the skin barrier and beyond

T Tsakok, R Woolf, CH Smith… - British Journal of …, 2019 - academic.oup.com
Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …

Stratum corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients

J Van Smeden, JA Bouwstra - Skin barrier function, 2016 - karger.com
Human skin acts as a primary barrier between the body and its environment. Crucial for this
skin barrier function is the lipid matrix in the outermost layer of the skin, the stratum corneum …

Does atopic dermatitis cause food allergy? A systematic review

T Tsakok, T Marrs, M Mohsin, S Baron, G du Toit… - Journal of Allergy and …, 2016 - Elsevier
Background The association between atopic dermatitis (AD) and food allergy (FA) is not fully
understood, although a causal relationship has been suggested. This has important …

[HTML][HTML] Research techniques made simple: transepidermal water loss measurement as a research tool

H Alexander, S Brown, S Danby, C Flohr - Journal of Investigative …, 2018 - Elsevier
Transepidermal water loss (TEWL) is the most widely used objective measurement for
assessing the barrier function of skin in healthy individuals but also patients with skin …

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

M Boguniewicz, DYM Leung - Immunological reviews, 2011 - Wiley Online Library
Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that
often precedes asthma and allergic disorders. New insights into the genetics and …

Impact of air pollution on atopic dermatitis: a comprehensive review

Z Pan, Y Dai, N Akar-Ghibril, J Simpson, H Ren… - Clinical Reviews in …, 2023 - Springer
Air pollution is associated with multiple health problems worldwide, contributing to increased
morbidity and mortality. Atopic dermatitis (AD) is a common allergic disease, and increasing …