The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells

A Kulesza, L Paczek, A Burdzinska - Biomedicines, 2023 - mdpi.com
The ability of MSCs to modulate the inflammatory environment is well recognized, but
understanding the molecular mechanisms responsible for these properties is still far from …

Harnessing prostaglandin E2 signaling to ameliorate autoimmunity

JB Burkett, AC Doran, M Gannon - Trends in immunology, 2023 - cell.com
The etiology of most autoimmune diseases remains unknown; however, shared among them
is a disruption of immunoregulation. Prostaglandin lipid signaling molecules possess …

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

CA Loynes, JA Lee, AL Robertson, MJG Steel… - Science …, 2018 - science.org
Neutrophils are the first immune cells recruited to a site of injury or infection, where they
perform many functions. Having completed their role, neutrophils must be removed from the …

EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid …

J So, D Wu, AH Lichtenstein, AK Tai, NR Matthan… - Atherosclerosis, 2021 - Elsevier
Background and aims The independent effects of eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid …

Resolvin D1 (RvD1) and maresin 1 (Mar1) contribute to human macrophage control of M. tuberculosis infection while resolving inflammation

A Ruiz, C Sarabia, M Torres, E Juárez - International immunopharmacology, 2019 - Elsevier
Resolvins and protectins counter inflammation, enhance phagocytosis, induce bactericidal/
permeability-increasing protein (BPI) expression, and restore inflamed tissue to …

The role of PGE2 and EP receptors on lung's immune and structural cells; possibilities for future asthma therapy

D Cebulla, C Van Geffen, S Kolahian - Pharmacology & Therapeutics, 2023 - Elsevier
Asthma is the most common airway chronic disease with treatments aimed mainly to control
the symptoms. Adrenergic receptor agonists, corticosteroids and anti-leukotrienes have …

Fibronectin induces macrophage migration through a SFK-FAK/CSF-1R pathway

G Digiacomo, I Tusa, M Bacci… - Cell adhesion & …, 2017 - Taylor & Francis
Integrins, following binding to proteins of the extracellular matrix (ECM) including collagen,
laminin and fibronectin (FN), are able to transduce molecular signals inside the cells and to …

Immunotoxicity in vitro assays for environmental pollutants under paradigm shift in toxicity tests

X Wang, N Li, M Ma, Y Han, K Rao - International Journal of …, 2022 - mdpi.com
With the outbreak of COVID-19, increasingly more attention has been paid to the effects of
environmental factors on the immune system of organisms, because environmental …

[HTML][HTML] Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression

J Xu, J Yang, A Nyga, M Ehteramyan, A Moraga, Y Wu… - Acta biomaterialia, 2018 - Elsevier
Histological assessments of synovial tissues from patients with failed CoCr alloy hip
prostheses demonstrate extensive infiltration and accumulation of macrophages, often …

Peritoneal lavage with Glycyrrhiza glabra is effective in preventing peritoneal adhesion in a rat model

H Rakhshandeh, V Baradaran Rahimi… - …, 2023 - Springer
Background Intraperitoneal adhesion formation is a significant problem following surgeries,
resulting in substantial clinical and economic consequences. Glycyrrhiza glabra has several …