Newer biologic and small-molecule therapies for inflammatory bowel disease

DC Baumgart, C Le Berre - New England Journal of Medicine, 2021 - Mass Medical Soc
Newer Biologic and Small-Molecule Therapies for IBD There is still no cure for inflammatory
bowel disease. This review covers newer treatments that reflect our understanding of the …

Prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases: a systematic review and meta-analysis

S Akiyama, S Hamdeh, D Micic… - Annals of the rheumatic …, 2021 - ard.bmj.com
Objectives The prevalence and clinical outcomes of COVID-19 in patients with autoimmune
diseases who are frequently treated with disease modifying therapies remains poorly …

The medical management of paediatric Crohn's disease: an ECCO-ESPGHAN guideline update

PF Van Rheenen, M Aloi, A Assa… - Journal of Crohn's …, 2021 - academic.oup.com
Objective We aimed to provide an evidence-supported update of the ECCO-ESPGHAN
guideline on the medical management of paediatric Crohn's disease [CD]. Methods We …

ECCO guidelines on the prevention, diagnosis, and management of infections in inflammatory bowel disease

T Kucharzik, P Ellul, T Greuter, JF Rahier… - Journal of Crohn's …, 2021 - academic.oup.com
The introduction and broad use of new immunosuppressive agents, including biologic
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …

Comparative efficacy and safety of biologic therapies for moderate-to-severe Crohn's disease: a systematic review and network meta-analysis

S Singh, MH Murad, M Fumery, R Sedano… - The Lancet …, 2021 - thelancet.com
Background Data are needed to inform the positioning of biologic therapy in the treatment of
moderate-to-severe Crohn's disease, both first line and after previous biologic exposure. We …

Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?

EJ Villablanca, K Selin, CRH Hedin - Nature Reviews Gastroenterology …, 2022 - nature.com
Almost all currently available treatments for inflammatory bowel disease (IBD) act by
inhibiting inflammation, often blocking specific inflammatory molecules. However, given the …

COVID-19 and immunomodulation in IBD

MF Neurath - Gut, 2020 - gut.bmj.com
The current coronavirus pandemic is an ongoing global health crisis due to COVID-19,
caused by severe acute respiratory syndrome coronavirus 2. Although COVID-19 leads to …

Ultrathin hafnium disulfide atomic crystals with ROS-scavenging and colon-targeting capabilities for inflammatory bowel disease treatment

R Li, Y Fan, L Liu, H Ma, D Gong, Z Miao, H Wang… - ACS …, 2022 - ACS Publications
The exciting success of NBTXR3 in the clinic has triggered a tumult of activities in the design
and development of hafnium-based nanoparticles. However, due to the concerns of …

COVID-19 pandemic-related mortality, infection, symptoms, complications, comorbidities, and other aspects of physical health among healthcare workers globally: an …

M Chutiyami, UM Bello, D Salihu, D Ndwiga… - International journal of …, 2022 - Elsevier
Background The COVID-19 pandemic has continued to cause unprecedented concern
across the globe since the beginning of the outbreak. Healthcare workers, particularly those …

Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn “der Deutschen Gesellschaft für Gastroenterologie, Verdauungs-und Stoffwechselkrankheiten …

A Sturm, R Atreya, D Bettenworth… - Zeitschrift für …, 2022 - thieme-connect.com
Im Jahr 2019 wurden etwa 25 500 Patient* innen mit M. Crohn im Krankenhaus stationär
behandelt [1]. Meistens tritt die Erkrankung in der Adoleszenz und im jungen …